Castleman's disease

noun

Cas·​tle·​man's disease ˈkas-əl-mənz- 

variants or Castleman disease

: a lymphoproliferative disorder characterized by enlargement of the lymph nodes due to benign overgrowth of lymphoid tissue

Note: Castleman's disease usually appears as a localized, often asymptomatic, lymphoid mass in a single lymph node, and rarely as a systemic illness that affects multiple lymph nodes and is marked especially by fever, weight loss, and fatigue.

Patients with localized Castleman's disease can be treated with surgical removal or radiation therapy.

—Phillip J. Bierman et al., in Cecil Textbook of Medicine, 22nd edition

Multicentric Castleman's disease causes lymphadenopathy, but systemic symptoms, including fevers with high temperatures, are also common and were not prominent in this case.

—Rajesh T. Gandhi et al., The New England Journal of Medicine

called also angiofollicular lymph node hyperplasia, giant lymph node hyperplasia